ADDITIONAL GENES WHICH RESULT IN AN ELEVATION OF ACETYLCHOLINE LEVELS BY MUTATIONS IN CAENORHABDITIS-ELEGANS

被引：46

作者：

HOSONO, R

KAMIYA, Y

机构：

[1] Department of Biochemistry, School of Medicine, Kanazawa University, Kanazawa

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 02期

关键词：

TRICHLORFON; C-ELEGANS; ACETYLCHOLINE; UNC-11; UNC-63; UNC-64;

D O I：

10.1016/0304-3940(91)90270-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Four mutant genes (unc-17, unc-18, unc-41 and unc-13) have been identified that result in abnormal accumulation of acetylcholine (ACh) [3, 4]. We have now identified 3 more such genes (unc-63, unc-11 and unc-64). In addition to the abnormal accumulation of ACh, mutants in these 7 genes possess common phenotypes in locomotion, resistance to inhibitors of acetylcholinesterase (AChE) and in post-embryonic development. These results suggest that the 7 genes are involved in some related functions.

引用

页码：243 / 244

页数：2

共 10 条

[1]

BRENNER S, 1974, GENETICS, V77, P71

[2]

CULOTTI JG, 1981, GENETICS, V97, P281

[3]

HOSONO R, 1989, ZOOL SCI, V6, P697

[4] MUTATIONS AFFECTING ACETYLCHOLINE LEVELS IN THE NEMATODE CAENORHABDITIS-ELEGANS [J].