HEPATITIS-C VIREMIA IN ADULTS WITH TYPE-2 AUTOIMMUNE HEPATITIS

被引：72

作者：

GARSON, JA ^{[1
]}

LENZI, M ^{[1
]}

RING, C ^{[1
]}

CASSANI, F ^{[1
]}

BALLARDINI, G ^{[1
]}

BRIGGS, M ^{[1
]}

TEDDER, RS ^{[1
]}

BIANCHI, FB ^{[1
]}

机构：

[1] UNIV BOLOGNA,CATTEDRA SEMEIOT MED,IST CLIN MED GEN & TERAPIA MED,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF MEDICAL VIROLOGY | 1991年 / 34卷 / 04期

关键词：

HEPATITIS-C VIRUS; VIREMIA; POLYMERASE CHAIN REACTION; AUTOIMMUNE HEPATITIS; LKM1; ANTIBODIES;

D O I：

10.1002/jmv.1890340405

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

引用

页码：223 / 226

页数：4

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