SERUM CATHEPSIN-B LEVELS AND URINARY-EXCRETION OF CATHEPSIN-B IN THE CANCER-PATIENTS WITH REMOTE METASTASIS

被引:31
作者
HIRANO, T [1 ]
MANABE, T [1 ]
TAKEUCHI, S [1 ]
机构
[1] TAKEUCHI DENT CLIN,EHIME,JAPAN
关键词
CATHEPSIN-B; REMOTE METASTASIS; CANCER PATIENT;
D O I
10.1016/0304-3835(93)90072-H
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients without remote metastasis were significantly higher than those in the control non-cancer patients. Moreover, these parameters in the cancer patients with remote (liver or lung) metastasis were significantly higher than those in the cancer patients without remote metastasis. After radical curative operations, these parameters were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor metastasis, and also suggest that these parameters might be possible indicators for tumor malignancy such as remote metastasis.
引用
收藏
页码:41 / 44
页数:4
相关论文
共 10 条
[1]   HUMAN CATHEPSIN-B1 - PURIFICATION AND SOME PROPERTIES OF ENZYME [J].
BARRETT, AJ .
BIOCHEMICAL JOURNAL, 1973, 131 (04) :809-+
[2]  
BIRD JWC, 1980, FED PROC, V39, P20
[3]   CATHEPSIN-B1 - LYSOSOMAL ENZYME THAT DEGRADES NATIVE COLLAGEN [J].
BURLEIGH, MC ;
BARRETT, AJ ;
LAZARUS, GS .
BIOCHEMICAL JOURNAL, 1974, 137 (02) :387-+
[4]  
DOBROSSY L, 1980, CANCER RES, V40, P3281
[5]  
MCDONALD JK, 1975, LIFE SCI, V17, P1269
[6]  
PIETRAS RJ, 1978, OBSTET GYNECOL, V52, P321
[7]   DIFFERENCES IN SECRETION OF PROTEINASE CATHEPSIN-B AT EDGES OF HUMAN BREAST CARCINOMAS AND FIBROADENOMAS [J].
POOLE, AR ;
TILTMAN, KJ ;
RECKLIES, AD ;
STOKER, TAM .
NATURE, 1978, 273 (5663) :545-547
[8]  
RECLIES AD, 1980, CANCER RES, V40, P550
[9]   LYSOSOMAL CATHEPSIN-B - CORRELATION WITH METASTATIC POTENTIAL [J].
SLOANE, BF ;
DUNN, JR ;
HONN, KV .
SCIENCE, 1981, 212 (4499) :1151-1153
[10]  
WEISS L, 1977, GANN MONOGR CANCER R, V20, P25