SERUM CATHEPSIN-B LEVELS AND URINARY-EXCRETION OF CATHEPSIN-B IN THE CANCER-PATIENTS WITH REMOTE METASTASIS

被引：31

作者：

HIRANO, T ^{[1
]}

MANABE, T ^{[1
]}

TAKEUCHI, S ^{[1
]}

机构：

[1] TAKEUCHI DENT CLIN,EHIME,JAPAN

来源：

CANCER LETTERS | 1993年 / 70卷 / 1-2期

关键词：

CATHEPSIN-B; REMOTE METASTASIS; CANCER PATIENT;

D O I：

10.1016/0304-3835(93)90072-H

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients without remote metastasis were significantly higher than those in the control non-cancer patients. Moreover, these parameters in the cancer patients with remote (liver or lung) metastasis were significantly higher than those in the cancer patients without remote metastasis. After radical curative operations, these parameters were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor metastasis, and also suggest that these parameters might be possible indicators for tumor malignancy such as remote metastasis.

引用

页码：41 / 44

页数：4

共 10 条

[1] HUMAN CATHEPSIN-B1 - PURIFICATION AND SOME PROPERTIES OF ENZYME [J].