CYTOSTATIC AND CYTOTOXIC ACTIVITY OF SEX STEROIDS AGAINST HUMAN LEUKEMIA-CELL LINES

被引：30

作者：

BLAGOSKLONNY, MV

NECKERS, LM

机构：

[1] Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD 20892, NC1

来源：

CANCER LETTERS | 1994年 / 76卷 / 2-3期

关键词：

LEUKEMIAS; ESTROGENS; PROGESTINS; CYTOSTASIS; CYTOTOXICITY;

D O I：

10.1016/0304-3835(94)90381-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated effects of sex steroids and analogs (estradiol, DES, norgestrel, progesterone, medroxyprogesterone, and testosterone) on the proliferation and survival of 10 human leukemia/lymphoma cell lines (HL-60, K562, U937, CEM, KG-1, Jurkat, U266, H929, PA and SUNHL). Micromolar concentrations of sex steroids exerted cytostatic and cytotoxic effects on all cell lines tested, irrespective of their sensitivity to glucocorticoids. The order of potency of sex hormones was: DES > progesterone greater than or equal to medroxyprogesterone > testosterone > estradiol >> norgestrel. For progesterone and estradiol, cytostatic effects can be achieved at lower concentrations than cytotoxic effects. The most potent agent, DES, exerted half maximal cytotoxic activity at a median concentration of 4 mu M (for 10 leukemia cell lines). Our results provide a basis for the potential therapeutic use of estrogens and progestins in glucocorticoid-resistant leukemias and lymphomas.

引用

页码：81 / 86

页数：6

共 13 条

[1] CORTICOSTEROIDS AND LYMPHOID-CELLS [J].