NOVEL SYNERGISTIC TREATMENT OF ETHANOL WITHDRAWAL SEIZURES IN RATS WITH DOPAMINE AND SEROTONIN AGONISTS

被引：24

作者：

MIROVSKY, Y

YU, YL

WAGNER, GC

SEKOWSKI, A

GOLDBERG, M

FISHER, H

机构：

[1] RUTGERS STATE UNIV,COOK COLL,DEPT NUTR SCI,NEW BRUNSWICK,NJ 08903

[2] RUTGERS STATE UNIV,DEPT PSYCHOL,NEW BRUNSWICK,NJ 08903

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1995年 / 19卷 / 01期

关键词：

ALCOHOL WITHDRAWAL; SEIZURES; ETHANOL; SEROTONIN; DOPAMINE;

D O I：

10.1111/j.1530-0277.1995.tb01485.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

A recent observation in this laboratory of a simultaneous increase in striatal dopamine and a decrease in serotonin in ethanol-dependent rats during ethanol withdrawal prompted studies with combined dopaminergic + serotoninergic agonists to stop withdrawal seizures, Amphetamine (2 mg/kg) + fenfluramine (8 mg/kg) given jointly, but not separately, prevented ethanol withdrawal seizures as effectively as benzodiazepines (chlordiazepoxide), the current drugs of choice. The combination of amphetamine and fenfluramine, unlike chlordiazepoxide, significantly reduced intake of ethanol during and immediately following ethanol withdrawal.

引用

页码：160 / 163

页数：4

共 19 条

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