STOPPED FOR REPAIRS

被引：62

作者：

SANCHEZ, Y ^{[1
]}

ELLEDGE, SJ ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030

来源：

BIOESSAYS | 1995年 / 17卷 / 06期

关键词：

D O I：

10.1002/bies.950170611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor protein p53 is intimately involved in the cellular response to DNA damage, controlling cell cycle arrest, apoptosis and the transcriptional induction of DNA damage inducible genes. A transcriptional target of p53, Gadd45, was recently found to bind to PCNA, a component of DNA replication/repair complexes, thereby implicating Gadd45 in DNA metabolism((1)). Using biochemical assays, a role for Gadd45 in excision repair in vitro has been demonstrated((1)). Antisense experiments have also indicated an in vivo role for the GADD45 gene in UV-irradiation survival. These discoveries establish a link between p53 and DNA repair through Gadd45.

引用

页码：545 / 548

页数：4

共 27 条

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