MER2 - A RED-CELL POLYMORPHISM DEFINED BY MONOCLONAL-ANTIBODIES

被引：11

作者：

DANIELS, GL

TIPPETT, P

PALMER, DK

MILLER, YE

GEYER, D

JONES, C

机构：

[1] UNIV LONDON UNIV COLL, MRC, BLOOD GRP UNIT, WOLFSON HOUSE, 4 STEPHENSON WAY, LONDON NW1 2HE, ENGLAND

[2] ELEANOR ROOSEVELT INST CANC RES, DENVER, CO USA

[3] VET ADM MED CTR, DENVER, CO 80220 USA

[4] UNIV COLORADO, HLTH SCI CTR, DEPT MED, DENVER, CO 80262 USA

[5] UNIV COLORADO, HLTH SCI CTR, DEPT BIOCHEM BIOPHYS & GENET, DENVER, CO 80262 USA

来源：

VOX SANGUINIS | 1987年 / 52卷 / 1-2期

关键词：

D O I：

10.1111/j.1423-0410.1987.tb03002.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two murine monoclonal antibodies, 1D12 and 2F7, apparently of the same specificity, define a new red cell polymorphism, MER2. 92% of English blood donors are MER2+ giving the gene frequencies MER2+ 0.7159; MER2- 0.2841. Family studies showed that MER2+ is inherited as a Mendelian dominant character and that MER2 is not controlled by any of the main blood group loci. The MER2 antigen antigen is also present on some leukaemia fibroblasts and human cell lines. Using somatic cell hydrids, MER2 appears to be coded for by a gene on chromsoosme 11 at 11p15.

引用

页码：107 / 110

页数：4

共 17 条

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