SOLUBLE INTERLEUKIN-2 RECEPTORS IN CHILDREN WITH KAWASAKI SYNDROME

被引：23

作者：

BARRON, KS ^{[1
]}

MONTALVO, JF ^{[1
]}

JOSEPH, AK ^{[1
]}

HILARIO, MO ^{[1
]}

SAADEH, C ^{[1
]}

GIANNINI, EH ^{[1
]}

ORSON, FM ^{[1
]}

机构：

[1] BAYLOR UNIV,HOUSTON,TX 77030

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 09期

关键词：

D O I：

10.1002/art.1780330909

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied levels of soluble interleukin‐2 receptors (IL‐2R) in serial serum samples obtained from 93 patients with Kawasaki syndrome, using a double‐antibody “sandwich” enzyme‐linked immunosorbent assay technique. Concentrations of soluble IL‐2R were significantly increased in Kawasaki syndrome patients in the first 4 weeks of illness when compared with either healthy adult or pediatric controls (P < 0.02), and in the first 2 weeks of illness when compared with a group of children with measles (P < 0.0001). Furthermore, in the second week of illness, levels of soluble IL‐2R were significantly greater in children who subsequently developed coronary artery aneurysms than in patients with normal appearing coronary arteries. Serum concentration of soluble IL‐2R is a useful marker for detecting early Kawasaki syndrome and identifies those patients who are at greater risk of developing coronary artery aneurysms. Copyright © 1990 American College of Rheumatology

引用

页码：1371 / 1377

页数：7

共 43 条

[1]

ASAI T, 1984, ACTA PEDIATR JPN, V2, P171

[2]

BARRON K, 1988, J RHEUMATOL, V15, P1243

[3] TREATMENT OF KAWASAKI SYNDROME [J].