EFFECT OF METHYL ISOCYANATE (MIC) ON RAT ERYTHROCYTES

被引：11

作者：

AGRAWAL, D

GUPTA, GSD

SHUKLA, JS

DUTTA, KK

RAY, PK

机构：

[1] Industrial Toxicology Research Centre, Lucknow - 226001 (U.P.), Mahatma Gandhi Marg

来源：

ARCHIVES OF TOXICOLOGY | 1990年 / 64卷 / 04期

关键词：

ATPase; Erythrocytes; Methyl isocyanate; Osmotic fragility; Scanning electron microscopy;

D O I：

10.1007/BF01972995

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Changes in surface morphology of rat erythrocytes were studied by scanning electron microscopy after a single and repeated exposure of methyl isocyanate under static conditions. Marked morphological changes (echinocytes and spherocytes) were observed, followed by an increase in osmotic fragility of the erythrocyte membrane. The activity of the membrane bound enzyme adenosine triphosphatase (Na+, K+, Mg++) was inhibited. © 1990 Springer-Verlag.

引用

页码：332 / 335

页数：4

共 13 条

[1] METHYL ISOCYANATE - A REVIEW OF HEALTH-EFFECTS RESEARCH SINCE BHOPAL [J].