THE USE OF A LOW-MOLECULAR-WEIGHT HEPARINOID (ORG 10172) FOR EXTRACORPOREAL PROCEDURES IN PATIENTS WITH HEPARIN DEPENDENT THROMBOCYTOPENIA AND THROMBOSIS

被引：33

作者：

ROWLINGS, PA ^{[1
]}

MANSBERG, R ^{[1
]}

ROZENBERG, MC ^{[1
]}

EVANS, S ^{[1
]}

MURRAY, B ^{[1
]}

机构：

[1] PRINCE WALES HOSP,DEPT HAEMATOL,RANDWICK,NSW 2031,AUSTRALIA

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | 1991年 / 21卷 / 01期

关键词：

HEPARIN; LOW MOLECULAR WEIGHT HEPARINOID; THROMBOCYTOPENIA; CARDIOPULMONARY BYPASS; HEMODIALYSIS;

D O I：

10.1111/j.1445-5994.1991.tb03003.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report two cases of heparin induced thrombocytopenia (HIT), in patients who required anticoagulation for extracorporeal procedures (haemodialysis and cardiopulmonary bypass) one associated with recurrent thrombosis of the artificial circuits. Resolution of thrombocytopenia and successful anticoagulation were achieved using a low molecular weight heparinoid (LMWH) Org 10172. Anticoagulation was monitored using estimations of plasma anti-factor Xa activity. These cases demonstrate that LMWH provides safe and effective anticoagulation in patients in whom unfractionated heparin has caused HIT.

引用

页码：52 / 54

页数：3

共 11 条

[1]

ADDONIZIO VP, 1987, SURGERY, P796

[2]

BARROWCLIFFE TW, 1988, THROMB HAEMOSTASIS, V60, P1

[3]

BELL WR, 1988, J LAB CLIN MED, V111, P600

[4]

BULL BS, 1975, J THORAC CARDIOV SUR, V69, P685

[5] HEPARIN-INDUCED THROMBOCYTOPENIA - EFFECT OF HEPARIN PLATELET ANTIBODY ON PLATELETS [J].

CHONG, BH ;

GRACE, CS ;

ROZENBERG, MC .

BRITISH JOURNAL OF HAEMATOLOGY, 1981, 49 (04) :531-540

[6]

GOLLUB S, 1962, J LAB CLIN MED, V59, P430

[7]

HATTERSLEY P, 1966, JAMA-J AM MED ASSOC, V136, P436

[8] PROTAMINE REVERSAL OF ANTICOAGULATION ACHIEVED WITH A LOW-MOLECULAR-WEIGHT HEPARIN - THE EFFECTS ON EICOSANOIDS, CLOTTING AND COMPLEMENT FACTORS [J].

LINDBLAD, B ;

BORGSTROM, A ;

WAKEFIELD, TW ;

WHITEHOUSE, WM ;

STANLEY, JC .

THROMBOSIS RESEARCH, 1987, 48 (01) :31-40

[9] MANAGEMENT OF PATIENTS WITH HEPARIN-ASSOCIATED THROMBOCYTOPENIA AND THROMBOSIS REQUIRING CARDIAC-SURGERY [J].

MAKHOUL, RG ;

MCCANN, RL ;

AUSTIN, EH ;

GREENBERG, CS ;

LOWE, JE .

ANNALS OF THORACIC SURGERY, 1987, 43 (06) :617-621

[10] EFFECT OF HEPARIN AND HEPARIN FRACTIONS ON PLATELET-AGGREGATION [J].

SALZMAN, EW ;

ROSENBERG, RD ;

SMITH, MH ;

LINDON, JN ;

FAVREAU, L .

JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (01) :64-73

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