SYNTHESIS AND ANTITUMOR-ACTIVITY OF 6-O-CARBOXYMETHYL CHITIN FIXING 5-FLUOROURACILS THROUGH PENTAMETHYLENE, MONOMETHYLENE SPACER GROUPS VIA AMIDE, ESTER BONDS

被引：12

作者：

OHYA, Y

INOSAKA, K

OUCHI, T

机构：

[1] Department Of Applied Chemistry, Faculty Of Engineering, Kansai University, Osaka 564, Suita

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期

关键词：

6-O-CARBOXYMETHYL CHITIN; 5-FLUOROURACIL; DRUG DELIVERY SYSTEM; MACROMOLECULAR PRODRUG; ANTITUMOR ACTIVITY; P388; LYMPHOCYTIC-LEUKEMIA;

D O I：

10.1248/cpb.40.559

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to provide the water-soluble and biodegradable macromolecular prodrug of 5-fluorouracil (5FU), the fixation of 5FUs to 6-O-carboxymethyl chitin(CM-chitin) through pentamethylene, monomethylene spacer groups via amide, ester bonds was carried out. The obtained CM-chitin/5FU conjugate showed the slow release of 5FU and exhibited remarkable antitumor activity against P388 lymphocytic leukemia in mice by intraperitoneal(i.p.) implantation / i.p. injection.

引用

页码：559 / 561

页数：3

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