PPADS, A NOVEL FUNCTIONALLY SELECTIVE ANTAGONIST OF P2 PURINOCEPTOR-MEDIATED RESPONSES

被引：275

作者：

LAMBRECHT, G ^{[1
]}

FRIEBE, T ^{[1
]}

GRIMM, U ^{[1
]}

WINDSCHEIF, U ^{[1
]}

BUNGARDT, E ^{[1
]}

HILDEBRANDT, C ^{[1
]}

BAUMERT, HG ^{[1
]}

SPATZKUMBEL, G ^{[1
]}

MUTSCHLER, E ^{[1
]}

机构：

[1] UNIV FRANKFURT,DEPT BIOCHIM & GENET MICROBIENNE,W-6000 FRANKFURT,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 217卷 / 2-3期

关键词：

PPADS; (PYRIDOXALPHOSPHATE-6-AZOPHENYL-2'; 4'-DISULFONIC ACID); P2 PURINOCEPTORS (ANTAGONISTS); VAS DEFERENS (RABBIT);

D O I：

10.1016/0014-2999(92)90877-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha(1)-adrenoceptors, muscarinic M2 and M3 receptors, histamine H-1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.

引用

页码：217 / 219

页数：3

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