PREPARATION OF RACEMIC CIS AND TRANS-2-(2-ALKOXYPHENYL-CARBAMOYLOXY)CYCLOHEPTYLMETHYLPIPERIDINIUM CHLORIDES

被引：9

作者：

GREGAN, F ^{[1
]}

KETTMANN, V ^{[1
]}

NOVOMESKY, P ^{[1
]}

SIVY, J ^{[1
]}

机构：

[1] COMENIUS UNIV BRATISLAVA,FAC PHARM,CS-83232 BRATISLAVA,SLOVAKIA

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1994年 / 59卷 / 03期

关键词：

D O I：

10.1135/cccc19940675

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of two pairs of the title diastereomers, which represent conformationally constrained analogues of the phenylcarbamate local anesthetics, is described. The synthesis was accomplished by starting from cycloheptanone and 2-alkoxyanilines and the intermediate diastercomers of 2-amino-methylcycloalkanols (VI, VII) were separated as their 4-nitrobenzoyl derivatives (IV, V) by extraction and fractional crystallization. The prepared compounds (VIIIa, VIllb, IXa, and IXb) are assumed to be of help in interpreting the structure-activity relationships within this class of drugs.

引用

页码：675 / 682

页数：8

共 19 条

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