AN ANALYSIS OF SEQUENCE VARIATION IN THE BETA-CHAIN FRAMEWORK AND COMPLEMENTARITY-DETERMINING REGIONS OF AN ALLOREACTIVE T-CELL RECEPTOR

被引：21

作者：

DIGIUSTO, DL

PALMER, E

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206

[2] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

来源：

MOLECULAR IMMUNOLOGY | 1994年 / 31卷 / 09期

基金：

美国国家卫生研究院;

关键词：

T CELL RECEPTOR; STRUCTURE; FRAMEWORK REGION; COMPLEMENTARITY DETERMINING REGIONS;

D O I：

10.1016/0161-5890(94)90179-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current models of T cell receptor (TCR) structure are generally based on the homology observed between the TCR and the immunoglobulins. Furthermore, these models have predicted the locations of framework and complementarity determining regions within the alpha- and beta-chain variable regions. In order to test the validity of these models, we have generated a series of mutations within the V beta domain of an allo-reactive TCR and determined their effect on antigen recognition.

引用

页码：693 / 699

页数：7

共 21 条

[1] 3-DIMENSIONAL STRUCTURE OF AN ANTIGEN-ANTIBODY COMPLEX AT 2.8-A RESOLUTION
AMIT, AG
MARIUZZA, RA
PHILLIPS, SEV
POLJAK, RJ
[J]. SCIENCE, 1986, 233 (4765) : 747 - 753
[2] MOLECULAR GENETIC-ANALYSIS OF 178 I-ABM12-REACTIVE T-CELLS
BILL, J
YAGUE, J
APPEL, VB
WHITE, J
HORN, G
ERLICH, HA
PALMER, E
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) : 115 - 133
[3] THE CONTRIBUTION OF MUTANT AMINO-ACIDS TO ALLOANTIGENICITY
BILL, J
RONCHESE, F
GERMAIN, RN
PALMER, E
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) : 739 - 750
[4] THE PREDICTED STRUCTURE OF IMMUNOGLOBULIN-D1.3 AND ITS COMPARISON WITH THE CRYSTAL-STRUCTURE
CHOTHIA, C
LESK, AM
LEVITT, M
AMIT, AG
MARIUZZA, RA
PHILLIPS, SEV
POLJAK, RJ
[J]. SCIENCE, 1986, 233 (4765) : 755 - 758
[5] THE OUTLINE STRUCTURE OF THE T-CELL ALPHA-BETA-RECEPTOR
CHOTHIA, C
BOSWELL, DR
LESK, AM
[J]. EMBO JOURNAL, 1988, 7 (12) : 3745 - 3755
[6] DAVIS MM, 1989, ADV EXP MED BIOL, V254, P13
[7] THE ANTIGEN-SPECIFIC, MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED RECEPTOR ON T-CELLS .6. AN ANTIBODY TO A RECEPTOR ALLOTYPE
HASKINS, K
HANNUM, C
WHITE, J
ROEHM, N
KUBO, R
KAPPLER, J
MARRACK, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (02) : 452 - 471
[8] SELECTION OF AMINO-ACID SEQUENCES IN THE BETA CHAIN OF THE T-CELL ANTIGEN RECEPTOR
HEDRICK, SM
ENGEL, I
MCELLIGOTT, DL
FINK, PJ
HSU, ML
HANSBURG, D
MATIS, LA
[J]. SCIENCE, 1988, 239 (4847) : 1541 - 1544
[9] MAPPING T-CELL RECEPTOR PEPTIDE CONTACTS BY VARIANT PEPTIDE IMMUNIZATION OF SINGLE-CHAIN TRANSGENICS
JORGENSEN, JL
ESSER, U
FAZEKAS DE ST GROTH, B
REAY, PA
DAVIS, MM
[J]. NATURE, 1992, 355 (6357) : 224 - 230
[10] KANAGAWA O, 1991, J IMMUNOL, V147, P1307

← 1 2 3 →