EFFECT OF INTRA-VENTRICULARLY INJECTED RICIN ON PROTEIN-SYNTHESIS IN RAT-BRAIN

被引：9

作者：

STROCCHI, P

NOVELLO, F

MONTANARO, N

STIRPE, F

机构：

[1] UNIV BOLOGNA,IST PATOL GEN,I-40126 BOLOGNA,ITALY

[2] MCLEAN HOSP,MAILMAN RES CTR,BELMONT,MA 02178

[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

NEUROCHEMICAL RESEARCH | 1979年 / 4卷 / 02期

关键词：

D O I：

10.1007/BF00964149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ricin, a protein from the seeds of Ricinus communis which inhibits protein synthesis by eukaryotic ribosomes, is highly toxic when injected intraventricularly to rats, the LD50 being 0.241 μg/rat at 72 hr and 0.084 μg/rat at 7 days. Poisoned animals showed signs of central depression; they did not die before 20 hr of intoxication. Incorporation of amino acids in vivo into brain total protein and into brain ribosomes was impaired, as was protein synthesis in vitro by microsomes isolated from the brain of poisoned rats. © 1979 Plenum Publishing Corporation.

引用

页码：259 / 268

页数：10

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