ARYLOXYALKYLOXY-4-HYDROXY-3-NITROCOUMARINS AND ARALKYLOXY-4-HYDROXY-3-NITROCOUMARINS WHICH INHIBIT HISTAMINE-RELEASE IN THE RAT AND ALSO ANTAGONIZE THE EFFECTS OF A SLOW REACTING SUBSTANCE OF ANAPHYLAXIS

被引：38

作者：

BUCKLE, DR

OUTRED, DJ

ROSS, JW

SMITH, H

SMITH, RJ

SPICER, BA

GASSON, BC

机构：

[1] Beecham Pharmaceuticals-Research Division, Brockham Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 02期

关键词：

D O I：

10.1021/jm00188a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and structure activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174. © 1979, American Chemical Society. All rights reserved.

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页码：158 / 168

页数：11

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