EFFECT OF ADRENERGIC AGONISTS ON HUMAN CHORIONIC-GONADOTROPIN RELEASE BY HUMAN TROPHOBLAST CELLS OBTAINED FROM 1ST-TRIMESTER PLACENTA

被引：11

作者：

OIKE, N

IWASHITA, M

MURAKI, T

NOMOTO, T

TAKEDA, Y

SAKAMOTO, S

机构：

[1] TOKYO WOMENS MED COLL,CTR MATERNAL & PERINATAL,SHINJUKU KU,TOKYO 162,JAPAN

[2] TOKYO WOMENS MED COLL,DEPT GYNAECOL & OBSTET,SHINJUKU KU,TOKYO 162,JAPAN

来源：

HORMONE AND METABOLIC RESEARCH | 1990年 / 22卷 / 03期

关键词：

Beta[!sub]2[!/sub] adrenoceptor; Cultured placental cells; Human chorionic gonadotropin; Ritodrine;

D O I：

10.1055/s-2007-1004880

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cultured syncytiotrophoblast cells from human first trimester placenta were used to determine the effect of adrenergic agonists on human chorionic gonadotropin (hCG) production in vitro. Beta-adrenergic agonists isoproterenol, ritodrine and isoxsuprine increased the hCG release during the 2 h incubation period, however, alpha-agonists norepinephrine and phenylephrine and a beta1-agonist dobutamine had no effect. The effect of isoproterenol was blocked by propranolol and butoxamine, but less efficiently by phentolamine and atenolol. These results indicate that placental hCG production can be modulated by stimulation of beta-, possibly beta2-adrenoceptors but not by alpha-adrenoceptors.

引用

页码：188 / 191

页数：4

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