ANTIGENS RECOGNIZED ON A MELANOMA CELL-LINE BY AUTOLOGOUS CYTOLYTIC LYMPHOCYTES-T ARE ALSO EXPRESSED ON FRESHLY COLLECTED TUMOR-CELLS

被引:23
作者
DEGIOVANNI, G
HAINAUT, P
LAHAYE, T
WEYNANTS, P
BOON, T
机构
[1] LUDWIG INST CANC RES, BRUSSELS, BELGIUM
[2] CATHOLIC UNIV LOUVAIN, B-1348 LOUVAIN LA NEUVE, BELGIUM
关键词
D O I
10.1002/eji.1830200835
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Peripheral blood lymphocytes of a melanoma patient were stimulated in vitro with a permanent cell line derived from the autologous tumor. Stable cytolytic T lymphocyte (CTL) clones were obtained that lysed the melanoma cell line and did not lyse autologous Epstein‐Barr virus‐transformed B lymphocytes or K‐562 cells. These CTL clones were directed against two distinct antigens on the melanoma line. In view of the possibility that these antigens could be culture artefacts, we tested the stimulatory ability of tumor cells that had been freshly collected from metastatic relapses on the CTL clones. A considerable CTL proliferation was observed and it appeared to be specific. We conclude that the antigens recognized by the autologous CTL clones on the permanent melanoma cell line were expressed by the tumor cells in the patient. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
引用
收藏
页码:1865 / 1868
页数:4
相关论文
共 20 条
[1]  
BRUNNER KT, 1980, J IMMUNOL, V124, P1627
[2]   ANTIGENIC HETEROGENEITY OF A HUMAN-MELANOMA TUMOR-DETECTED BY AUTOLOGOUS CTL CLONES [J].
DEGIOVANNI, G ;
LAHAYE, T ;
HERIN, M ;
HAINAUT, P ;
BOON, T .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (05) :671-676
[3]  
DEVRIES JE, 1984, J IMMUNOL, V132, P510
[4]  
Gross L, 1943, CANCER RES, V3, P326
[5]   PRODUCTION OF STABLE CYTOLYTIC T-CELL CLONES DIRECTED AGAINST AUTOLOGOUS HUMAN-MELANOMA [J].
HERIN, M ;
LEMOINE, C ;
WEYNANTS, P ;
VESSIERE, F ;
VANPEL, A ;
KNUTH, A ;
DEVOS, R ;
BOON, T .
INTERNATIONAL JOURNAL OF CANCER, 1987, 39 (03) :390-396
[6]   CRITIQUE OF EVIDENCE FOR ACTIVE HOST DEFENCE AGAINST CANCER, BASED ON PERSONAL STUDIES OF 27 MURINE TUMORS OF SPONTANEOUS ORIGIN [J].
HEWITT, HB ;
BLAKE, ER ;
WALDER, AS .
BRITISH JOURNAL OF CANCER, 1976, 33 (03) :241-259
[7]   CYTOLYTIC T-CELL CLONES AGAINST AN AUTOLOGOUS HUMAN-MELANOMA - SPECIFICITY STUDY AND DEFINITION OF 3 ANTIGENS BY IMMUNOSELECTION [J].
KNUTH, A ;
WOLFEL, T ;
KLEHMANN, E ;
BOON, T ;
ZUMBUSCHENFELDE, KHM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2804-2808
[8]   T-CELL-MEDIATED CYTO-TOXICITY AGAINST AUTOLOGOUS MALIGNANT-MELANOMA - ANALYSIS WITH INTERLEUKIN 2-DEPENDENT T-CELL CULTURES [J].
KNUTH, A ;
DANOWSKI, B ;
OETTGEN, HF ;
OLD, LJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (11) :3511-3515
[9]   ANTIGENICITY OF MURINE SKIN TUMORS INDUCED BY ULTRAVIOLET-LIGHT [J].
KRIPKE, ML .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 53 (05) :1333-1336
[10]   CELL-MEDIATED CYTOTOXICITY FOR CULTURED AUTOLOGOUS MELANOMA-CELLS [J].
LIVINGSTON, PO ;
SHIKU, H ;
BEAN, MA ;
PINSKY, CM ;
OETTGEN, HF ;
OLD, LJ .
INTERNATIONAL JOURNAL OF CANCER, 1979, 24 (01) :34-44