C-ERBB-2 ONCOGENE EXPRESSION IN OVARIAN-CANCER

被引：84

作者：

HALDANE, JS

HIRD, V

HUGHES, CM

GULLICK, WJ

机构：

[1] HAMMERSMITH HOSP,DEPT RADIOTHERAPY,LONDON W12 0HS,ENGLAND

[2] HAMMERSMITH HOSP,IMPERIAL CANC RES FUND,ONCOL GRP,LONDON W12 0HS,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1990年 / 162卷 / 03期

关键词：

cancer; c‐erbB‐2; multivariate analysis; Oncogene; ovary;

D O I：

10.1002/path.1711620309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One hundred and four common epithelial malignancies of the ovary were stained for c‐erbB‐2 using an affinity‐purified polyclonal antibody 21N. Twenty‐three out of 104 (22·1 per cent) showed cytoplasmic staining alone. Nine out of 104 (8·7 per cent) showed both membrane and cytoplasmic staining. In a multivariate Cox analysis with other known risk factors the relative risk for cytoplasmic staining alone was 1·456 (χ2=1·71, P>0·1) and for membrane and cytoplasmic staining 0·316 (χ2=7·95, P < 0·005). These results do not support an adverse prognostic effect of c‐erbB‐2 in our patients. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：231 / 237

页数：7

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