HEMORPHINS DERIVED FROM HEMOGLOBIN HAVE AN INHIBITORY-ACTION ON ANGIOTENSIN CONVERTING ENZYME-ACTIVITY

被引：93

作者：

LANTZ, I

GLAMSTA, EL

TALBACK, L

NYBERG, F

机构：

[1] Uppsala University, Department of Pharmacology, S-751 24 Uppsala

来源：

FEBS LETTERS | 1991年 / 287卷 / 1-2期

关键词：

HEMORPHIN; ACE-ACTIVITY; INHIBITION; BLOOD PRESSURE REGULATION; HPLC; MASS SPECTROMETRY;

D O I：

10.1016/0014-5793(91)80011-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hemorphins are opioid active peptides, which are enzymatically released from the beta-chain of hemoglobin. In this paper we report an inhibitory effect of these peptides on angiotensin converting enzyme (ACE) activity, known to be involved in blood pressure regulation. The hemorphins were found to be quite stable in tissue extracts containing ACE, and their importance as naturally occurring ACE inhibitors is discussed.

引用

页码：39 / 41

页数：3

共 13 条

[1] NOVEL OPIOID-PEPTIDES DERIVED FROM HEMOGLOBIN - HEMORPHINS [J].