EXPRESSION OF THE TUMOR SUPPRESSOR GENE P53 IN ORAL-CANCER

被引：82

作者：

LANGDON, JD ^{[1
]}

PARTRIDGE, M ^{[1
]}

机构：

[1] KINGS COLL,SCH MED & DENT,MAXILLOFACIAL UNIT,DENMARK HILL,LONDON SE5 8RX,ENGLAND

来源：

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY | 1992年 / 30卷 / 04期

关键词：

D O I：

10.1016/0266-4356(92)90263-I

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

In this preliminary series, the product of the tumour suppressor gene p53 was detected in 12/15 cases of oral squamous cell carcinoma (SCC) and in two cases of leukoplakia. The tumours either expressed the mutant form of p53 throughout the specimen or contained focal areas of positive cells. p53 expression was commonly observed in tumours obtained from patients who were heavy smokers and drinkers suggesting that alterations in the p53 gene may be one of the sites of genetic damage in this group of patients.

引用

页码：214 / 220

页数：7

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