BIOGENETICALLY DIVERSE, BIOACTIVE CONSTITUENTS OF A SPONGE, ORDER VERONGIDA - BROMOTYRAMINES AND SESQUITERPENE-SHIKIMATE DERIVED METABOLITES

From a Verongid sponge, family Aplysinellidae and most likely a member of an undescribed genus, we have isolated respectable quantities of a bromotyramine derivative, moloka'iamine (1) and of puupehenone (5) related compounds. When broken apart, the animal emits hydrogen cyanide. The structures were determined spectrally and by comparison with published data. Puupehenone-related metabolites 2 and 4-8 exhibit a variety of biological activities (cyotoxicity, antiviral, antifungal, immunomodulatory) to varying degrees. 1, 6-Addition to the conjugated dienone system of puupehenone (5) enhances some of the activities.