FEASIBILITY OF EVANESCENT-WAVE INTERFEROMETER IMMUNOSENSORS FOR PESTICIDE DETECTION - CHEMICAL ASPECTS

被引：16

作者：

LECHUGA, LM ^{[1
]}

LENFERINK, ATM ^{[1
]}

KOOYMAN, RPH ^{[1
]}

GREVE, J ^{[1
]}

机构：

[1] UNIV TWENTE,MESA RES INST,DEPT APPL PHYS,BIOINTERFACE GRP,7500 AE ENSCHEDE,NETHERLANDS

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1995年 / 25卷 / 1-3期

关键词：

EVANESCENT WAVE INTERFEROMETER; IMMUNOSENSORS; PESTICIDE DETECTION;

D O I：

10.1016/0925-4005(95)85169-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A waveguide Mach-Zehnder Interferometer (MZI) immunosensor has been developed which can detect, in a direct way, a minimum average layer growth thickness of the analyte of 2x10(-3) nn (bound mass, Gamma=1x10(-4) mu g cm(-2)). The design and fabrication of the sensor and the experimental set-up are aimed at decreasing the detection limit. A flow cell has been designed and incorporated into the set-up to allow a high mass-transport rate of the analyte molecules to the sensor surface, in this way decreasing the net response time. Results for the immunosystem alpha-hSA/hSA are presented. All improvements have been done as a first step towards the use of the MZI immunosensor in the direct detection of low coverages of pesticides with an expected layer growth of 2x10(-4) nm.

引用

页码：762 / 765

页数：4

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