COMPARISON OF EFFECTS OF NICARDIPINE AND TRICHLORMETHIAZIDE ON INSULIN SENSITIVITY IN HYPERTENSIVE PATIENTS

被引：3

作者：

KAGEYAMA, S

YAMAMOTO, J

MIMURA, A

ISHIBASHI, K

SAKURAI, T

YOKOTA, K

ISOGAI, Y

FUJITA, T

机构：

[1] Department of Internal Medicine (III), Jikei University School of Medicine, Tokyo

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 05期

关键词：

INSULIN RESISTANCE; NICARDIPINE; THIAZIDE; GLUCOSE CLAMP;

D O I：

10.1093/ajh/7.5.474

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We performed a randomized, crossover study comparing the effects of nicardipine and trichlormethiazide on insulin sensitivity in 8 untreated essential hypertensive patients. They were treated either with nicardipine or trichlormethiazide for 12 weeks, after which they were treated with the alternative drug for a further 12 weeks. Insulin sensitivity was determined by the hyperinsulinemic euglycemic clamp technique. Nicardipine had no adverse effect on insulin sensitivity. Trichlormethiazide decreased insulin sensitivity index by 12%. As nicardipine does not have an adverse effect on insulin sensitivity, it should be preferred in patients who have a proven metabolic abnormality.

引用

页码：474 / 477

页数：4

共 15 条

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