SALMETEROL INHIBITS ANAPHYLACTIC HISTAMINE-RELEASE FROM GUINEA-PIG ISOLATED MAST-CELLS

被引：4

作者：

GENTILINI, G

DIBELLO, MG

RASPANTI, S

BINDI, D

MUGNAI, S

ZILLETTI, L

机构：

[1] Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, 50134

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03725.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Salmeterol (1 nM-100 mu M) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 mu M). This study supports the hypothesis of an antiinflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.

引用

页码：76 / 77

页数：2

共 14 条

[1]

BAKER A J, 1990, American Review of Respiratory Disease, V141, pA394

[2]

BRADSHAW J, 1987, British Journal of Pharmacology, V92, p590P

[3] SALMETEROL - A POTENT AND LONG-ACTING INHIBITOR OF INFLAMMATORY MEDIATOR RELEASE FROM HUMAN LUNG [J].

BUTCHERS, PR ;

VARDEY, CJ ;

JOHNSON, M .

BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (03) :672-676

[4]

DAHL R, 1991, American Review of Respiratory Disease, V143, pA649

[5]

DALE MM, 1965, IMMUNOLOGY, V8, P435

[6]

GORENNE I, 1992, PHARM RES S1, V26, P33

[7]

JOHNSON M, 1991, AGENT ACTION SUPPL, V34, P79

[8] A PROCEDURE FOR DETERMINATION OF HISTAMINE [J].

KREMZNER, LT ;

WILSON, IB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 50 (02) :364-&

[9]

OSHAUGHNESSY KM, 1991, LANCET, V337, P45

[10] ISOLATION AND SOME PROPERTIES OF MAST-CELLS FROM THE MESENTERY OF THE RAT AND GUINEA-PIG [J].

PEARCE, FL ;

ENNIS, M .

AGENTS AND ACTIONS, 1980, 10 (1-2) :124-131

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