SYNTHESIS AND ANTICANDIDAL ACTIVITIES OF OPTIMIZED ANALOGS OF ANTIBIOTIC SCH-37137

被引：9

作者：

ANDRUSZKIEWICZ, R

ZIENIAWA, T

CHMARA, H

KASPRZAK, L

BOROWSKI, E

机构：

[1] Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 06期

关键词：

D O I：

10.7164/antibiotics.47.715

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N-3-(trans-epoxysuccinamoyl)-L-2,3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (D)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of. diastereomers of Sch 37137.

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页码：715 / 723

页数：9

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