FUNCTIONAL AND DYNAMIC ASPECTS OF THE MAMMALIAN NUCLEOLUS

被引：266

作者：

SCHEER, U

BENAVENTE, R

机构：

[1] Institute of Zoology I, University of Würzburg, Würzburg, D-8700

来源：

BIOESSAYS | 1990年 / 12卷 / 01期

关键词：

D O I：

10.1002/bies.950120104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleoli are the sites of ribosome biogenesis. Transcription of the ribosomal RNA genes as well as processing and initial packaging of their transcripts with ribosomal and non‐ribosomal proteins all occur within the nucleolus in an ordered manner and under defined topological conditions. Components of the nucleolus have been localized by immunocytochemistry and their functional aspects investigated by microinjection of antibodies directed against the enzyme responsible for rDNA transcription, RNA polymerase I. The role of nascent transcripts in postmitotic formation of nucleoli will be discussed. Copyright © 1990 Cambridge University Press

引用

页码：14 / 21

页数：8

共 38 条

[1]

ARROUA ML, 1982, BIOL CELL, V44, P337

[2] INHIBITION OF NUCLEOLAR REFORMATION AFTER MICROINJECTION OF ANTIBODIES TO RNA POLYMERASE-I INTO MITOTIC CELLS [J].