HORMONAL-REGULATION OF THE MENSTRUAL-CYCLE IN WOMEN WITH BREAST-CANCER - EFFECT OF ADJUVANT CHEMOTHERAPY

被引：21

作者：

SHERMAN, BM

WALLACE, RB

JOCHIMSEN, PR

机构：

[1] UNIV IOWA,COLL MED,DEPT INTERNAL MED,IOWA CITY,IA 52242

[2] UNIV IOWA,COLL MED,DEPT SURG,IOWA CITY,IA 52242

[3] UNIV IOWA,COLL MED,DEPT PREVENT MED,IOWA CITY,IA 52242

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 03期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb02083.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hormonal features of the menstrual cycle determined by measurement of serum LH, FSH, oestradiol, progesterone and prolactin were normal in thirteen breast cancer patients clinically disease free and not taking anti‐tumour therapy. Results of similar studies during seven menstrual cycles in four patients on an adjuvant therapy programme of L‐phenylalanine mustard (L‐PAM) + 5‐flurouracil (5‐FU) also had normal hormonal characteristics after three to fourteen courses of chemotherapy. Amenorrhoea with elevated gonadotrophins occurred after seven courses of chemotherapy in one 48‐year‐old woman. Adjuvant chemotherapy does not appear to result in major alterations in hormone secretion during menstrual cycles of women who continue to menstruate while on therapy. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：287 / 296

页数：10

共 24 条

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