NEUROPEPTIDE-Y AND VASOACTIVE-INTESTINAL-PEPTIDE IN EXPERIMENTAL SUBARACHNOID HEMORRHAGE - IMMUNOCYTOCHEMISTRY, RADIOIMMUNOASSAY AND PHARMACOLOGY

被引：14

作者：

EDVINSSON, L

ALAFACI, C

DELGADO, T

EKMAN, R

JANSEN, I

SVENDGAARD, NA

UDDMAN, R

机构：

[1] UNIV LUND,MALMO GEN HOSP,DEPT EXPTL RES,S-21401 MALMO,SWEDEN

[2] UNIV LUND,MALMO GEN HOSP,DEPT OTORHINOLARYNGOL,S-21401 MALMO,SWEDEN

[3] UNIV LUND HOSP,DEPT NEUROSURG,S-22185 LUND,SWEDEN

[4] UNIV LUND HOSP,DEPT PSYCHIAT & NEUROCHEM,S-22185 LUND,SWEDEN

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1991年 / 83卷 / 02期

关键词：

NEUROPEPTIDE-Y; NORADRENALINE; ACETYLCHOLINE; VIP; SUBARACHNOID HEMORRHAGE; CEREBRAL ARTERY; RAT;

D O I：

10.1111/j.1600-0404.1991.tb04658.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The involvement of noradrenaline (NA), neuropeptide Y, (NPY), 5-hydroxytryptamine (5-HT), acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) has been examined in the late phase of spasm after an experimental subarachnoid hemorrhage (SAH) in a rat model. Immunocytochemistry and radioimmunoassay of blood vessels from the circle of Willis did not show significant differences in NPY- and VIP-like immunoreactivity 2 days post SAH as compared to control vessels. The postjunctional effects of NA, NPY, 5-HT, ACh and VIP were studied two days after SAH using a sensitive in vitro system. NPY induced contractions were significantly (p < 0.01) weaker (lower E(max)) in SAH as compared to control rats while the relaxant responses to ACh and VIP were slightly increased after SAH. These observations reveal that in a rat model of SAH, with an approximately 20% in vivo constriction at two days, dynamic changes occur in cerebral artery reactivity despite any obvious change in sympathetic or parasympathetic perivascular nerve networks.

引用

页码：103 / 109

页数：7

共 27 条

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