CYCLOSPORINE-A, FK506 AND RAPAMYCIN - MORE THAN JUST IMMUNOSUPPRESSION

被引：256

作者：

KUNZ, J

HALL, MN

机构：

[1] Department of Biochemistry, Biocenter, University of Basel, CH4056 Basel

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 09期

关键词：

D O I：

10.1016/0968-0004(93)90069-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

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页码：334 / 338

页数：5

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