NOVEL-APPROACH FOR DETERMINING OPTIMAL TREATMENT REGIMEN FOR CANCER-CHEMOTHERAPY

被引：5

作者：

ABULESZ, EM

LYBERATOS, G

机构：

[1] Univ of Florida, Gainesville, FL,, USA, Univ of Florida, Gainesville, FL, USA

来源：

INTERNATIONAL JOURNAL OF SYSTEMS SCIENCE | 1988年 / 19卷 / 08期

关键词：

DRUG PRODUCTS - Dosage - OPTIMIZATION;

D O I：

10.1080/00207728808964051

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A procedure is proposed which allows the determination of the optimal treatment regimen for cancer chemotherapy given a certain patient and drug. The pi -criterion is applied to a mathematical model describing malignant and benign cell growth and destruction. As a result, the clinician can see whether the drug under consideration will have the desired effect as well as which form of treatment would be preferable: cyclic (on/off) or continuous. In the event cyclic treatment is superior, the optimal length of the treatment cycle as well as the on/off time for medication and the optimal dosage during this time are determined.

引用

页码：1483 / 1497

页数：15

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