PREPARATION OF OPTICALLY ACTIVE CHLOROFLUOROACETIC ACID AND CHLOROFLUOROETHANOL

被引：20

作者：

BELLUCCI, G

BERTI, G

BORRACCI.A

MACCHIA, F

机构：

[1] Institute of Organic Chemistry, University of Pisa

来源：

TETRAHEDRON | 1969年 / 25卷 / 15期

关键词：

D O I：

10.1016/S0040-4020(01)82831-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(±)-Chlorofluoroacetic acid (1) has been resolved into its enantiomers through the dehydroabietylamine salts; LAH reduction of methyl (-)-chlorofluoroacetate has given (-)-chlorofluoroethanol. An approximate estimation of the optical purity of (-)-1 has been carried out by a GLPC method. Partial kinetic resolutions of (±)-1 have been achieved through reactions with half-molar amounts of 5,6α-epoxy-5α-cholestan-3β-ol and 5,6β-epoxy-5β-cholestan-3β-ol. © 1969.

引用

页码：2979 / &

共 27 条

[1] Resolution of racemic chlorobromoacetic acid [J].