A NEW H-OXIME RESTORES RAT DIAPHRAGM CONTRACTILITY AFTER ESTERASE INHIBITION INVITRO

被引：21

作者：

ALBERTS, P ^{[1
]}

机构：

[1] SWEDISH DEF RES ESTAB,DIV EXPTL MED,S-90182 UMEA,SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 184卷 / 01期

关键词：

Acetylcholine esterase reactivators; Diaphragm; HI; 6; HLö; 7; Obidoxime; Pralidoxime;

D O I：

10.1016/0014-2999(90)90682-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetylcholine esterase inhibitors block cholinergic neurotransmission. This blockade can be reversed by oximes. However, a universally effective esterase reactivator does not exist. A new H-oxime, HLö 7, was tested on rat diaphragm strips. Electrically evoked contractions were blocked by di-2-propyl fluorophosphate (DEP), tabun, sarin and soman. Whereas pralidoxime, obidoxime and HI 6 reversed the blockade induced by three of these organophosphorus compounds, HLö 7 restored the contractions after short blockade induced by all four organophosphorus compounds tested. © 1990.

引用

页码：191 / 194

页数：4

共 9 条

[1]

ALBERTS P, 1986, 2ND P INT S PROT CHE, P287

[2]

ECOBICHON DJ, 1982, PESTICIDES NEUROLOGI, P151

[3]

ENDRES W, 1989, J PHARMACOL EXP THER, V251, P1181

[4]

LOFFLER M, 1986, THESIS A LUDWIGS U F, P1

[5]

Luttringhaus A., 1964, ARZNEIMITTELFORSCHUN, V14, P1

[6] INSECTICIDES AND NERVE GASES - POISONING AND THERAPY [J].

STARK, I .

CHEMIE IN UNSERER ZEIT, 1984, 18 (03) :96-106

[7]

Taylor P., 1985, GOODMAN GILMANS PHAR, P110

[8] SUCCESSFUL OXIME THERAPY ONE HOUR AFTER SOMAN INTOXICATION IN RAT [J].

WOLTHUIS, OL ;

KEPNER, LA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 49 (04) :415-425

[9] EFFECTS OF P2S TMB4 AND LUH6 ON RAT PHRENIC NERVE DIAPHRAGM PREPARATION TREATED WITH SOMAN OR TABUN [J].

WOLTHUIS, OL ;

COHEN, EM .

BIOCHEMICAL PHARMACOLOGY, 1967, 16 (02) :361-&

← 1 →