SMALL ANIMAL MRI AT 0.35 TESLA - GROWTH AND MORPHOLOGY OF INTRAORGAN MURINE TUMORS

被引：6

作者：

BUTTON, TM ^{[1
]}

FIEL, RJ ^{[1
]}

GOLDROSEN, M ^{[1
]}

PAOLINI, N ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT BIOPHYS,BUFFALO,NY 14263

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 04期

关键词：

MRI; Murine tumors;

D O I：

10.1016/0730-725X(90)90059-B

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A whole-body small animal radiofrequency coil was designed and built for use with a 0.35 Tesla clinical magnetic resonance imager. The primary motivation for this work was to evaluate the effectiveness of this system for small animal magnetic resonance imaging of tumor-bearing mice. This noninvasive technique is shown to provide high resolution whole-body images of mice, to be capable of detecting intra-organ tumors, and to be useful for evaluating tumor size and growth. Its potential for monitoring response to experimental therapeutic regimens is also noted. Two tumor models were examined-colon adenocarcinoma MCA-38 and human ASPC-1 pancreatic adenocarcinoma. © 1990.

引用

页码：505 / 509

页数：5

共 6 条

[1]

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[2]

Fiel, Button, Gilani, Et al., Proton relaxation enhancement by manganese(III)TPPS<sub>4</sub> in a model tumor system, Magn. Reson. Imaging, 5, pp. 149-156, (1987)

[3]

Goldrosen, Paolini, Holyoke, Description of a murine model of experimental hepatic metastases, J. Natl. Cancer Inst., 77, pp. 823-828, (1986)

[4]

Goldrosen, Loftus, Lloyd, Biddle, Paolini, Holyoke, Foon, Localization of monoclonal antibody in a novel nude mouse model of pancreatic cancer, Proc. Am. Assoc. Cancer Res., 29, (1988)

[5]

Button, An investigation of potential tumor-specific magnetic resonance contrast agents and imaging of model tumor systems, Ph.D. Dissertation, (1989)

[6]

Valentine, Yamanaski, Patil, Et al., Non-invasive tumor volume measurement using magnetic resonance imaging and an open sided saddle coil, Physiol. Chem. Phys. Med. NMR, 18, pp. 103-108, (1986)

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