INCREASED ERYTHROCYTE LIPID PEROXIDATION IN HEREDITARY XEROCYTOSIS

被引：20

作者：

HARM, W

FORTIER, NL

LUTZ, HU

FAIRBANKS, G

SNYDER, LM

机构：

[1] ST VINCENT HOSP,DIV HEMATOL,WORCESTER,MA 01604

[2] WORCESTER FDN EXPTL BIOL,SHREWSBURY,MA 01545

来源：

CLINICA CHIMICA ACTA | 1979年 / 99卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0009-8981(79)90034-2

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Xerocytosis is a chronic hemolytic anemia with abnormal membrane function manifested by an increase in passive potassium permeability. Xerocytes demonstrate a greater susceptibility to hydrogen peroxide manifested by the production of malondialdehyde (MDA). Xerocyte membrane phospholipid and fatty acid analysis is normal except for a slight increase in phosphatidyl choline, a commensurate decrease in sphingomyelin, as well as a decrease in linoleic acid. Metabolism and glutathione stability are normal as well as plasma vitamin E levels in patients with xerocytosis. The increased susceptibility to oxidant stress is exaggerated in the older aged" xerocyte population and correlated well with decreased intracellular potassium concentration. © 1979."

引用

页码：121 / 128

页数：8

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