RELEASE OF CA-2+ FROM HEART AND KIDNEY MITOCHONDRIA BY PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR LIGANDS

被引：22

作者：

MORENOSANCHEZ, R ^{[1
]}

BRAVO, C ^{[1
]}

GUTIERREZ, J ^{[1
]}

NEWMAN, AH ^{[1
]}

CHIANG, PK ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR,WASHINGTON,DC 20307

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 02期

关键词：

D O I：

10.1016/0020-711X(91)90191-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The effect of the benzodiazepines Ro5-4864, AHN 086 and clonazepam on the release of Ca2+ from rat heart and kidney mitochondria was studied. 2. The peripheral-type benzodiazepines Ro5-4864 and AHN 086 induced Ca2+ release which was blocked by Mg2+ whereas the central-type benzodiazepine clonazepam was ineffective. 3. An associated collapse of membrane potential and swelling were also induced by AHN 086 in the presence of Ca2+. 4. However, no oxidation of pyridine nucleotides or increased rate or respiration were observed. 5. Release of Sr2+ was induced by AHN 086 in the absence of inorganic phosphate but not in its presence. 6. These data are discussed in the context of the current hypotheses on the mechanism of mitochondrial Ca2+ release.

引用

页码：207 / 213

页数：7

共 43 条

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