STRUCTURE ELUCIDATION OF L-687,781, A NEW BETA-1,3-D-GLUCAN SYNTHESIS INHIBITOR

被引：16

作者：

VANMIDDLESWORTH, F

DUFRESNE, C

SMITH, J

WILSON, KE

机构：

[1] Merck, Sharp and Dohme Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON | 1991年 / 47卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(01)88280-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new beta-1,3 glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. Through NMR, mass spectroscopy, and degradation studies the structure of L-687,781 was determined to be 1, a novel member of the papulacandin family of antifungal agents. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

引用

页码：7563 / 7568

页数：6

共 13 条

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