COMPENSATORY REGIONAL CONTRACTION FOLLOWING CORONARY-ARTERY OCCLUSION DEPENDS ON SUBENDOCARDIAL HYPEREMIA AND HYPERKINESIA

被引:16
作者
BIRKELAND, S
WESTBY, J
HEXEBERG, E
GRONG, K
LEKVEN, J
机构
[1] Surgical Research Laboratory, Department of Surgery, University of Bergen, Haukeland Hospital
关键词
SEGMENT SHORTENING; MYOCARDIAL CONTRACTION; MYOCARDIAL BLOOD FLOW; MYOCARDIAL ISCHEMIA;
D O I
10.1093/oxfordjournals.eurheartj.a060339
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of circumflex coronary artery occlusion on regional myocardial performance and blood flow in the left ventricular anterior wall was studied, using 16 thoracotomized pentobarbital-anaesthetized cats. Two pairs of ultrasonic crystals were placed in the midwall; one segment (longitudinal) parallel to the subendocardial fibres, the other (circumferential) being aligned to the fibres of the outer half-layer. A shunt line from the right subclavian artery to the main left coronary artery was unrestricted in eight cats (Group A) and clamped in another eight cats (Group B) until coronary perfusion pressure was clearly reduced with only a minor reduction in shunt flow, but without changes in global cardiac function. After circumflex coronary occlusion hyperkinesis was most pronounced in segments parallel to subendocardial fibres (longitudinal), also validated as a marked leftward shift in the end-systolic pressure-length relation of these segments. Such a shift may indicate decreased regional afterload along the cardiac major axis. Hyperkinesis of longitudinal segments was attenuated in Group B where a fixed shunt stenosis hampered subendocardial and mid-myocardial hyperaemia. The lesser hyperkinesis of Group B was associated with decreased left ventricular systolic pressure and cardiac output. Thus, impaired compensatory contraction outside an acute ischaemic region was produced by a significant coronary stenosis which precluded the subendocardial hyperaemia and hyperkinesis of that region. © 1992 The European Society of Cardiology.
引用
收藏
页码:1207 / 1216
页数:10
相关论文
共 43 条
[1]   MAXIMAL NEGATIVE DP-DT AS AN INDICATOR OF END OF SYSTOLE [J].
ABEL, FL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 240 (04) :H676-H679
[2]  
[Anonymous], 1971, STAT PRINCIPLES EXPT
[3]   END-SYSTOLIC MEASURES OF REGIONAL VENTRICULAR PERFORMANCE [J].
AVERSANO, T ;
MAUGHAN, WL ;
HUNTER, WC ;
KASS, D ;
BECKER, LC .
CIRCULATION, 1986, 73 (05) :938-950
[4]   GRADUAL REDUCTION OF CORONARY PERFUSION-PRESSURE IN CATS - CHANGES IN TRANSMURAL DISTRIBUTION OF BLOOD-FLOW [J].
BIRKELAND, S ;
HEXEBERG, E ;
MATRE, K ;
KVITTING, P ;
WESTBY, J ;
LEKVEN, J ;
GRONG, K .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1990, 50 (07) :787-796
[5]   COMPENSATORY SUBENDOCARDIAL HYPERKINESIA IN THE CAT IS ABOLISHED DURING CORONARY INSUFFICIENCY OUTSIDE AN ACUTELY ISCHEMIC REGION [J].
BIRKELAND, S ;
WESTBY, J ;
HESSEVIK, I ;
GRONG, K ;
HEXEBERG, E ;
LEKVEN, J .
CARDIOVASCULAR RESEARCH, 1992, 26 (03) :285-291
[6]   SENSITIVITY OF END-SYSTOLIC PRESSURE-DIMENSION AND PRESSURE-VOLUME RELATIONS TO THE INOTROPIC STATE IN HUMANS [J].
BOROW, KM ;
NEUMANN, A ;
WYNNE, J .
CIRCULATION, 1982, 65 (05) :988-997
[7]  
BRUTSAERT DL, 1984, ACTA CARDIOL, V34, P89
[8]  
DIXON WJ, 1985, BMDP STATISTICAL SOF
[9]   REGIONAL EPICARDIAL AND ENDOCARDIAL 2-DIMENSIONAL FINITE DEFORMATIONS IN CANINE LEFT-VENTRICLE [J].
FANN, JI ;
SARRIS, GE ;
INGELS, NB ;
NICZYPORUK, MA ;
YUN, KL ;
DAUGHTERS, GT ;
DERBY, GC ;
MILLER, DC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (05) :H1402-H1410
[10]   RELATIONSHIP BETWEEN MYOCARDIAL FIBER DIRECTION AND SEGMENT SHORTENING IN THE MIDWALL OF THE CANINE LEFT-VENTRICLE [J].
FREEMAN, GL ;
LEWINTER, MM ;
ENGLER, RL ;
COVELL, JW .
CIRCULATION RESEARCH, 1985, 56 (01) :31-39