DIVERSITY OF CYTOPLASMIC FUNCTIONS FOR THE 3' UNTRANSLATED REGION OF EUKARYOTIC TRANSCRIPTS

被引:221
作者
DECKER, CJ [1 ]
PARKER, P [1 ]
机构
[1] UNIV ARIZONA, HOWARD HUGHES MED INST, TUCSON, AZ 85721 USA
关键词
D O I
10.1016/0955-0674(95)80094-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The 3' untranslated region (3' UTR) can control gene expression by affecting the localization, stability and translation of mRNAs. The recent finding that 3'UTRs can control the decapping rate of mRNAs, in combination with their ability to influence the initiation of translation, suggests that 3' UTRs act through a direct or indirect interaction between the 3' and 5' ends of mRNAs.
引用
收藏
页码:386 / 392
页数:7
相关论文
共 73 条
  • [1] Ahringer, Kimble, Control of the sperm-oocyte switch in Ceanorhabditis elegans hermaphrodites by the fem-3 3′untranslated region, Nature, 349, pp. 346-348, (1991)
  • [2] Wharton, Struhl, RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos, Cell, 67, pp. 955-967, (1991)
  • [3] Kruys, Watherlet, Poupart, Contreras, Fiers, Content, Huez, The 3′ untranslated region of the human interferon-β mRNA has an inhibitory effect on translation, Proc Natl Acad Sci USA, 84, pp. 6030-6034, (1987)
  • [4] Ostareck-Lederer, Ostereck, Standart, Thiele, Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region, EMBO J, 13, pp. 1476-1481, (1994)
  • [5] Wickens, In the beginning is the end: regulation of poly(A) addition and removal during early development, Trends Biochem Sci, 15, pp. 320-324, (1990)
  • [6] Richter, Translational control during early development, Bioessays, 13, pp. 179-183, (1991)
  • [7] Fox, Sheets, Wickens, Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU, Genes Dev, 3, pp. 2151-2162, (1989)
  • [8] McGrew, Dworkin-Rastl, Dworkin, Richter, Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element, Genes Dev, 3, pp. 803-815, (1989)
  • [9] Vassalli, Huarte, Belin, Gubler, Vassallia O'Connell, Paton, Rickles, Strickland, Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes, Genes Dev, 3, pp. 2163-2171, (1989)
  • [10] Sheets, Fox, Hunt, Van De Woude, Wickens, The 3′-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation, Genes Dev, 8, pp. 926-938, (1994)