TESTICULAR DYSFUNCTION IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED MEN

被引:63
作者
PORETSKY, L [1 ]
CAN, S [1 ]
ZUMOFF, B [1 ]
机构
[1] ALBERT EINSTEIN COLL MED,BETH ISRAEL MED CTR,DEPT MED,DIV ENDOCRINOL & METAB,NEW YORK,NY
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1995年 / 44卷 / 07期
关键词
D O I
10.1016/0026-0495(95)90250-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This review pertains to gonadal function in men with human immunodeficiency virus (HIV) infection, who often exhibit clinical and biochemical evidence of hypogonadism. Hypogonadotropic hypogonadism appears to be the most commonly encountered abnormality, although complete anterior pituitary insufficiency and primary gonadal failure have been reported. Levels of sex hormone-binding globulin (SHBG) are either unchanged or increased. Plasma levels of estrogens, progesterone, androstenedione, dehydroepiandrosterone sulfate (DHEA-S), and prolactin vary. Pathologically, except for involvement by opportunistic infections, no significant abnormality in the hypothalamic-pituitary area has been described, but evidence of orchitis is commonly present. The cause(s) of these abnormalities remains unclear. The possible factors leading to hypogonadism in HIV-infected men include HIV infection itself, opportunistic infections, chronic debilitating illness, and effects of cytokines on the hypothalamic-pituitary-gonadal axis. Further studies are needed to clarify the cause(s) of testicular dysfunction in HIV-infected men and its clinical significance, treatment, relevance to the progression of HIV infection, and influence on the immune system. Copyright (C) 1995 by W.B. Saunders Company
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收藏
页码:946 / 953
页数:8
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