PROTEIN SYNTHESIS DIRECTED BY RIBOPOLYNUCLEOTIDE CONTAINING FORMYCIN

被引：13

作者：

IKEHARA, M

MURAO, K

HARADA, F

NISHIMUR.S

机构：

[1] Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Toneyama

[2] Virology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 174卷 / 02期

关键词：

D O I：

10.1016/0005-2787(69)90298-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulation of the binding of aminoacyl-tRNA to ribosomes was studied using ribopolynucleotide containing formycin (F). Poly (FC) stimulated the binding of [14C]His-tRNA about 50% as much as poly (AC). The binding of [14C]Thr-tRNA was stimulated almost equally by poly (AC) and poly (FC). In the protein synthesizing systems of Escherichia coli in vitro, poly (FC) directed the synthesis of poly (His-Thr) and poly (FG) directed poly (ArgGlu) synthesis. No mistranslation was observed. Tm of poly (FU) was slightly lower than that of poly (AU). © 1969.

引用

页码：696 / &

共 25 条

[1]

ANZAI K, 1957, J ANTIBIOT, V10, P201

[2] SYNTHETIC DEOXYRIBO-OLIGONUCLEOTIDES AS TEMPLATES FOR DNA POLYMERASE OF ESCHERICHIA COLI - NEW DNA-LIKE POLYMERS CONTAINING REPEATING NUCLEOTIDE SEQUENCES [J].