ANTIGENIC ANALYSIS OF MYCOBACTERIUM-LEPRAE

被引：59

作者：

CLOSS, O

MSHANA, RN

HARBOE, M

机构：

[1] University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, Oslo

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb02735.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

About twenty distinct antigenic components have been demonstrated in Mycubacterium leprae (M. leprae) by crossed immunoelectrophoresis against a rabbit antiserum produced by immunization with concentrated M, leprae antigen. This system allows a more detailed analysis of the antigenic relationship between M, leprae and other mycobacteria and a better characterization of the antigenic content of various M. leprae preparations than with previously available antisera which reacted with tar fewer components. The antibody activity in sera of patients with lepro‐matous leprosy was studied by incorporating the sera into the intermediate gel of the M. leprae reference system. Antibodies were found against only seven of the components. Since those compared are all known to be cross‐reacting widely with antigens of other mycobacteria, it is speculated that cross‐immunization may influence the antibody response in lepromatous leprosy. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：297 / 302

页数：6

共 12 条

[1]

AXELSEN NH, 1973, SCAND J IMMUNOL S, V2, P1

[2] EXPERIMENTAL MURINE LEPROSY .9. ANTIBODIES AGAINST MYCOBACTERIUM-LEPRAEMURIUM IN C3H AND C57BL MICE WITH MURINE LEPROSY AND IN PATIENTS WITH LEPROMATOUS LEPROSY [J].