COBYRIC ACID RELATED COMPOUNDS FROM VITAMIN B12

被引：21

作者：

BONNETT, R

GODFREY, JM

REDMAN, DG

机构：

[1] Chemistry Department, Queen Mary College

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 08期

关键词：

D O I：

10.1039/j39690001163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under controlled conditions cobyric acid is obtained directly (10%) by the action of concentrated hydrochloric acid on vitamin B12. The hydrolysis is complicated not only by the expected formation of other corrinoids of the normal series, but also by the formation of a second series of compounds which are darker than the normal derivatives, and which are related to Factor Ia. Cobinamide and Factor Ia may conveniently be obtained by the action of trifluoroacetic acid upon vitamin B12.

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页码：1163 / &

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