EFFECT OF CADMIUM ON THE BONE-FORMATION IN CULTURED FETAL-RAT CALVARIA

被引：3

作者：

IWAMI, K

DOHI, Y

MORIYAMA, T

机构：

[1] Dept. of Public Health, Nara Medical University, Kashihara, Nara

来源：

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 1990年 / 27卷 / 1-3期

关键词：

D O I：

10.1080/02772249009357563

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To clarify the toxic effect of Cadmium (Cd) on bone, alkaline phosphatase (ALP) activity, which is an osteoblastic marker produced during bone formation, and DNA synthesis were examined in cultures of 21-day old fetal rat calvaria. Both ALP activity and DNA synthesis were decreased by Cd. Probably Cd affected some stage of mineralization or cell differentiation in bone formation of calvaria. Zn coexisting in the culture medium prevented the inhibitory effect of Cd on ALP activity and DNA synthesis. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：105 / 111

页数：7

共 13 条

[1] STUDIES ON CALF-INTESTINAL ALKALINE PHOSPHATASE .1. CHROMATOGRAPHIC PURIFICATION, MICROHETEROGENEITY AND SOME OTHER PROPERTIES OF PURIFIED ENZYME [J].