PARTIALLY ORGANIC DISSOLUTION MEDIUM FOR GRISEOFULVIN DOSAGE FORMS

被引：12

作者：

WALKLING, WD

NAYAK, RK

PLOSTNIEKS, J

CRESSMAN, WA

机构：

[1] Research Division McNeil Laboratories Fort, Wasinghton, PA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1979年 / 5卷 / 01期

关键词：

D O I：

10.3109/03639047909055659

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Forty percent alcohol in simulated gastric fluid was used as a dissolution medium for two griseofulvin dosage forms. Rank-order correlation of dissolution profiles with plasma levels was obtained. The use of this partially organic dissolution medium for griseofulvin dosage forms is suggested as a convenient alternative to entirely aqueous media employed in large volumes (18 to 72 liters per dosage form). © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：17 / 27

页数：11

共 7 条

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[6] GRISEOFULVIN ABSORPTION IN MAN AFTER SINGLE AND REPEATED TREATMENTS AND ITS CORRELATION WITHDISSOLUTION RATES
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NAKANO, M
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[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1974, 2 (06): : 487 - 493

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