Crossed signals: oncogenic transcription factors

被引：24

作者：

Forrest, Douglas ^{[1
]}

Curran, Tom ^{[1
]}

机构：

[1] Roche Inst Mol Biol, Dept Mol Oncol & Virol, Nutley, NJ 07110 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1992年 / 2卷 / 01期

关键词：

CAII; cAMP-dependent protein kinase; carbonic anhydrase II; PKA; PKC; protein kinase C; RA; reticuloendotheliosis virus-T; retinoic acid; REV-T; T3 response elements; T3REs; thyroid-hormone receptor; TR;

D O I：

10.1016/S0959-437X(05)80316-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcription factors operate at key regulatory junctions in the cell's responses to diverse extracellular stimuli. We discuss how the transforming activity of mutated transcription factors encoded by several oncogenes (v-erbA, v-fos, v-jun and v-rel) may result in part from a loss of the integrated response to the signalling network.

引用

页码：19 / 27

页数：9

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