ACETYLCHOLINE ACTIVATES 2 TYPES OF ION CHANNELS IN SARCOLEMMA FROM ADULT MUSCULAR DYSTROPHIC (MDX) MICE

被引：7

作者：

KOLTGEN, D

FRANKE, C

机构：

[1] Physiologisches Institut der Technischen Universität München, München

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 01期

关键词：

MUSCULAR DYSTROPHY; ION CHANNEL; NICOTINIC ACETYLCHOLINE RECEPTOR; CALCIUM; MDX MOUSE;

D O I：

10.1016/0304-3940(92)90284-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dissociated interosseus muscle fibres of wildtype and mdx mice were investigated to characterize acetylcholine (ACh) receptors with the single channel recording patch-clamp technique. On the muscle fibres of mdx mutants, two types of nicotinic acetylcholine receptor (nAChR) channels were found. One channel (29 pS, mean open time 2.1 ms) resembles channels on denervated and embryonic muscle and was not found on wildtype muscle where exclusively a 48 pS channel (mean open time 1.3 ms) was seen.

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页码：1 / 4

页数：4

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