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TRANSCRANIAL DOPPLER TO EVALUATE THE EFFECTS OF ANTIHYPERTENSIVE MEDICATION ON CEREBRAL BLOOD-FLOW VELOCITY

被引：6
作者：
FAGAN, SC
BINDLISH, V
ROBERT, S
STEIGERWALT, SP
RAMADAN, NM
机构：
[1] HENRY FORD HOSP,DEPT PHARM,DETROIT,MI 48202
[2] HENRY FORD HOSP,DEPT INTERNAL MED,DETROIT,MI 48202
[3] HENRY FORD HOSP,DEPT NEUROL,DETROIT,MI 48202
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 32卷 / 01期
关键词：
D O I：
10.1002/j.1552-4604.1992.tb03790.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of oral nifedipine on cerebral blood flow velocity was studied in six elderly hypertensive patients using transcranial Doppler. Serial measurements of blood pressure (BP), middle cerebral artery (MCA) flow velocity and nifedipine serum concentrations were obtained over an 8-hour period. The authors found a significant inverse relationship between MCA velocities and nifedipine concentrations, independent of BP changes. These results are consistent with a direct vasodilatory effect of nifedipine on cerebral vessels and support the use of TCD in pharmacodynamic investigations of the cerebral vasculature.
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页码：66 / 69
页数：4
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