VARIABLE GENE USAGE, PHYSIOLOGY AND DEVELOPMENT OF LY-1+ (CD5+) B-CELLS

被引：49

作者：

HARDY, RR

机构：

[1] Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 02期

关键词：

D O I：

10.1016/0952-7915(92)90010-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two related features of Ly-1+ B cells (CD5+ B cells in man) are their biased specificities and variable gene usage, and their relationship to the bulk of Ly-1- ('conventional') B cells. An emerging model views Ly-1+ B cells as a memory population in the adult animal, whose generation is largely limited to fetal and neonatal development. Selection based on germline-encoded self-reactivity then shapes the adult repertoire.

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页码：181 / 185

页数：5

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