PHARMACOKINETICS AND BIODISTRIBUTION OF RADIOLABELED AVIDIN, STREPTAVIDIN AND BIOTIN

被引：65

作者：

ROSEBROUGH, SF

机构：

[1] Department of Radiology, University of Rochester Medical Center, Rochester

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 05期

关键词：

D O I：

10.1016/0969-8051(93)90037-U

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The extraordinary high affinity of avidin and streptavidin for biotin may be exploited in a two-step approach for delivering radiolabeled biotin derivatives suitable for imaging and therapy to target-bound streptavidin or avidin conjugated monoclonal antibodies (MAbs). The in vivo pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin (SA) and DTPA-biocytinamide (DTPA biotin) were studied in the rabbit and dog. SA circulated in the blood similar to other 60 kDa proteins, avidin cleared immediately and DTPA biotin exhibited plasma clearance by glomerular filtration.

引用

页码：663 / 668

页数：6

共 28 条

[1] RADIOLABELED ANTIFIBRIN ANTIBODY IN THE DETECTION OF VENOUS THROMBOSIS - PRELIMINARY-RESULTS [J].